Corticobasal degeneration presenting with nonfluent primary progressive aphasia: A clinicopathological study

Masaru Mimura, Tatsuro Oda, Kuniaki Tsuchiya, Motoichiro Kato, Kenji Ikeda, Koji Hori, Haruo Kashima

研究成果: Article査読

48 被引用数 (Scopus)

抄録

A 62-year-old woman initially presented with slowly progressive nonfluent aphasia with minimal intellectual involvement. Echolalia and personality change were prominent whereas parkinsonian features and signs suggesting parietal lobe dysfunctions were not present. The patient's language deficit was consistent with transcortical motor aphasia. She did not manifest extrapyramidal signs. The patient was diagnosed as having Pick's disease or frontal lobe dementia. She died at age 65, 2 years and 9 months following disease onset. Neuropathological findings including cytoskeletal abnormalities, however, were clearly distinct from those of classical Pick's disease and were consistent with those reported in corticobasal degeneration (CBD). The distribution of her cortical lesions was accentuated in the frontal language-related area. The clinical manifestations in CBD are diverse, and primary progressive nonfluent aphasia should be considered as an initial symptom of CBD. Neuropathological examination of such patients should include cytoskeletal abnormality studies.

本文言語English
ページ(範囲)19-26
ページ数8
ジャーナルJournal of the Neurological Sciences
183
1
DOI
出版ステータスPublished - 2001 1 15
外部発表はい

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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