Corticotropin-releasing hormone and dopamine release in healthy individuals

Doris Payer, Belinda Williams, Esmaeil Mansouri, Suzanna Stevanovski, Shinichiro Nakajima, Bernard Le Foll, Stephen Kish, Sylvain Houle, Romina Mizrahi, Susan R. George, Tony P. George, Isabelle Boileau

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Corticotropin-releasing hormone (CRH) is a key component of the neuroendocrine response to stress. In animal models, CRH has been shown to modulate dopamine release, and this interaction is believed to contribute to stress-induced relapse in neuropsychiatric disorders. Here we investigated whether CRH administration induces dopamine release in humans, using positron emission tomography (PET). Eight healthy volunteers (5 female, 22–48 years old) completed two PET scans with the dopamine D2/3 receptor radioligand [11C]-(+)-PHNO: once after saline injection, and once after injection of corticorelin (synthetic human CRH). We also assessed subjective reports and measured plasma levels of endocrine hormones (adrenocorticotropic hormone and cortisol). Relative to saline, corticorelin administration decreased binding of the D2/3 PET probe [11C]-(+)-PHNO, suggesting dopamine release. Endocrine stress markers were also elevated, in line with activation of the hypothalamic-pituitary-adrenal axis, but we detected no changes in subjective ratings. Preliminary results from this proof-of-concept study suggests that CRH challenge in combination with [11C]-(+)-PHNO PET may serve as an assay of dopamine release, presenting a potential platform for evaluating CRH/dopamine interactions in neuropsychiatric disorders and CRH antagonists as potential treatment avenues.

本文言語English
ページ(範囲)192-196
ページ数5
ジャーナルPsychoneuroendocrinology
76
DOI
出版ステータスPublished - 2017 2 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 内分泌系および自律システム
  • 精神医学および精神衛生
  • 生物学的精神医学

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