Cosecretion of peptides derived from gamma-human atrial natriuretic polypeptide in normal volunteers and patients with essential hypertension and adrenal disorders

Akira Sugawara, Kazuwa Nakao, Hiroshi Itoh, Takayuki Yamada, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Gotaro Shirakami, Narito Morii, Shozo Shiono, Hiroo Imura

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Using two radio-immunoassays for N-terminal and C-terminal fragments of human atrial natriuretic polypeptide (ANP) precursor, γ-hANP [human atrial natriuretic factor- (1-126)], that is γ -hANP(1-25) [human atrial natriuretic factor-(1-25)] and α-hANP [human atrial natriuretic factor-(99-126)], we studied the secretion of γ -hANP-derived peptides into circulation from the heart in normal subjects and patients with essential hypertension and adrenal disorders. Volume expansion with 2 litres physiological saline increased plasma γ -hANP(1-25)-like immunoreactivity concomitantly with plasma α - hANP-like immunoreactivity in normal subjects. Infusion of angiotensin II (20 ng/kg per min) or noradrenaline (200 ng/kg per min) also caused a parallel increase in plasma γ -hANP(1-25)-like and α -hANP-like immunoreactivity. Plasma γ -hANP(1-25)-like immunoreactivity levels were changed together with α -hANP-like immunoreactivity in patients with essential hypertension and adrenal disorders. These results indicate that γ -hANP-derived peptides, α -hANP and the 10-k N- terminal fragment of γ -hANP (N-peptide) are cosecreted from the heart and that the simultaneous measurement of N-peptide and α -hANP serves as an indicator of the cardiac endocrine function. The significance of N-peptide as a hormone must await further clarification.

本文言語English
ページ(範囲)S327-S329
ジャーナルJournal of Hypertension, Supplement
6
4
DOI
出版ステータスPublished - 1988 12
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学

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