Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations

Shigeki Sekine, Tatsuhiro Shibata, Akiko Kokubu, Yukio Morishita, Masayuki Noguchi, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article

148 引用 (Scopus)

抄録

Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.

元の言語English
ページ(範囲)1997-2001
ページ数5
ジャーナルAmerican Journal of Pathology
161
発行部数6
出版物ステータスPublished - 2002 12 1
外部発表Yes

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Craniopharyngioma
Catenins
Mutation
Genes
Carcinogenesis
Neoplasms
Microdissection
Epithelial Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

これを引用

Sekine, S., Shibata, T., Kokubu, A., Morishita, Y., Noguchi, M., Nakanishi, Y., ... Hirohashi, S. (2002). Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. American Journal of Pathology, 161(6), 1997-2001.

Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. / Sekine, Shigeki; Shibata, Tatsuhiro; Kokubu, Akiko; Morishita, Yukio; Noguchi, Masayuki; Nakanishi, Yukihiro; Sakamoto, Michiie; Hirohashi, Setsuo.

:: American Journal of Pathology, 巻 161, 番号 6, 01.12.2002, p. 1997-2001.

研究成果: Article

Sekine, S, Shibata, T, Kokubu, A, Morishita, Y, Noguchi, M, Nakanishi, Y, Sakamoto, M & Hirohashi, S 2002, 'Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations', American Journal of Pathology, 巻. 161, 番号 6, pp. 1997-2001.
Sekine S, Shibata T, Kokubu A, Morishita Y, Noguchi M, Nakanishi Y その他. Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. American Journal of Pathology. 2002 12 1;161(6):1997-2001.
Sekine, Shigeki ; Shibata, Tatsuhiro ; Kokubu, Akiko ; Morishita, Yukio ; Noguchi, Masayuki ; Nakanishi, Yukihiro ; Sakamoto, Michiie ; Hirohashi, Setsuo. / Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. :: American Journal of Pathology. 2002 ; 巻 161, 番号 6. pp. 1997-2001.
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AU - Noguchi, Masayuki

AU - Nakanishi, Yukihiro

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