Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations

Shigeki Sekine, Tatsuhiro Shibata, Akiko Kokubu, Yukio Morishita, Masayuki Noguchi, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article

159 引用 (Scopus)

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Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of β-catenin gene mutation to tumorigenesis, we examined genetic alterations and expression of β-catenin in 10 cases of adamantinomatous and 6 cases of papillary craniopharyngiomas. β-Catenin gene mutations were found in all of the adamantinomatous and none of the papillary craniopharyngiomas. Immunohistochemically, all cases of adamantinomatous craniopharyngioma showed cytoplasmic and nuclear expression of β-catenin. In contrast, papillary craniopharyngiomas showed exclusively membranous expression. The results suggest that adamantinomatous- and papillary-type craniopharyngiomas are not only clinicopathologically, but also genetically, distinctive variants. Mutation of the β-catenin gene therefore seems to play an important role in the tumorigenesis of adamantinomatous craniopharyngioma. Among the adamantinomatous-type tumors, β-catenin-positive mesenchymal cells were observed in two cases. Microdissection-based mutational analysis revealed that these mesenchymal cells also harbor the same β-catenin gene mutations as those of epithelial cells, suggesting their tumorous nature. Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic.

元の言語English
ページ(範囲)1997-2001
ページ数5
ジャーナルAmerican Journal of Pathology
161
発行部数6
DOI
出版物ステータスPublished - 2002 12 1
外部発表Yes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Sekine, S., Shibata, T., Kokubu, A., Morishita, Y., Noguchi, M., Nakanishi, Y., Sakamoto, M., & Hirohashi, S. (2002). Craniopharyngiomas of adamantinomatous type harbor β-Catenin gene mutations. American Journal of Pathology, 161(6), 1997-2001. https://doi.org/10.1016/S0002-9440(10)64477-X