Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses

Rika Ouchida, Hiromi Mori, Koji Hase, Hiroyuki Takatsu, Tomohiro Kurosaki, Takeshi Tokuhisa, Hiroshi Ohno, Ji Yang Wang

研究成果: Article査読

84 被引用数 (Scopus)

抄録

IgM antibodies have been known for decades to enhance humoral immune responses in an antigen-specific fashion. This enhancement has been thought to be dependent on complement activation by IgM-antigen complexes; however, recent genetic studies render this mechanism unlikely. Here, we describe a likely alternative explanation; mice lacking the recently identified Fc receptor for IgM (FcμR) on B cells produced significantly less antibody to protein antigen during both primary and memory responses. This immune deficiency was accompanied by impaired germinal center formation and decreased plasma and memory B-cell generation. FcμR did not affect steady-state B-cell survival but specifically enhanced the survival and proliferation induced by B-cell receptor cross-linking. Moreover, FcμR-deficient mice produced far more autoantibodies than control mice as they aged, suggesting that FcμR is also required for maintaining tolerance to self-antigens. Our results thus define a unique pathway mediated by the FcμR for regulating immunity and tolerance and suggest that IgM antibodies promote humoral immune responses to foreign antigen yet suppress autoantibody production through at least two pathways: complement activation and FcμR.

本文言語English
ページ(範囲)E2699-E2708
ジャーナルProceedings of the National Academy of Sciences of the United States of America
109
40
DOI
出版ステータスPublished - 2012 10 2
外部発表はい

ASJC Scopus subject areas

  • 一般

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