Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle

Noriaki Shimizu, Noritada Yoshikawa, Naoki Ito, Takako Maruyama, Yuko Suzuki, Sin Ichi Takeda, Jun Nakae, Yusuke Tagata, Shinobu Nishitani, Kenji Takehana, Motoaki Sano, Keiichi Fukuda, Makoto Suematsu, Chikao Morimoto, Hirotoshi Tanaka

研究成果: Article査読

292 被引用数 (Scopus)

抄録

Maintenance of skeletal muscle mass relies on the dynamic balance between anabolic and catabolic processes and is important for motility, systemic energy homeostasis, and viability. We identified direct target genes of the glucocorticoid receptor (GR) in skeletal muscle, i.e., REDD1 and KLF15. As well as REDD1, KLF15 inhibits mTOR activity, but via a distinct mechanism involving BCAT2 gene activation. Moreover, KLF15 upregulates the expression of the E3 ubiquitin ligases atrogin-1 and MuRF1 genes and negatively modulates myofiber size. Thus, GR is a liaison involving a variety of downstream molecular cascades toward muscle atrophy. Notably, mTOR activation inhibits GR transcription function and efficiently counteracts the catabolic processes provoked by glucocorticoids. This mutually exclusive crosstalk between GR and mTOR, a highly coordinated interaction between the catabolic hormone signal and the anabolic machinery, may be a rational mechanism for fine-tuning of muscle volume and a potential therapeutic target for muscle wasting.

本文言語English
ページ(範囲)170-182
ページ数13
ジャーナルCell Metabolism
13
2
DOI
出版ステータスPublished - 2011 2 2

ASJC Scopus subject areas

  • 生理学
  • 分子生物学
  • 細胞生物学

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