Cryptogenic fulminant hepatic failure in infancy: Report of 2 cases with unique vascular obstructive changes in native livers

Naoki Shimojima, Rie Shibata, Ken Hoshino, Shigeyuki Kawachi, Minoru Tanabe, Go Wakabayashi, Motohide Shimazu, Michiie Sakamoto, Yasuhide Morikawa, Masaki Kitajima

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Although the causes of fulminant hepatic failure (FHF) remain cryptogenic in many cases, a few reports have reviewed the pathological findings of native livers to evaluate the etiology. We report 2 cases of infantile cryptogenic FHF with unique vascular obstructive changes in the native livers. Clinically, it was notable that these 2 patients developed FHF very early in life, at 2 months and 5 months of age, respectively. One patient died from chronic rejection associated with hepatic veno-occlusive disease 4 months after transplantation. Histologically, hepatocytes in the native livers were completely destroyed in both patients, and vascular findings revealed obstruction of central veins in 1 patient and obstruction of portal veins in the other patient. Although the pathogenesis of vascular obstructions is not yet understood, this study suggests that an obstructive vascular event may be a contributing etiologic factor of FHF in infancy.

本文言語English
ページ(範囲)1418-1422
ページ数5
ジャーナルLiver Transplantation
12
9
DOI
出版ステータスPublished - 2006 9月

ASJC Scopus subject areas

  • 外科
  • 肝臓学
  • 移植

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