Current Aspects of Pediatric Pharmacokinetics and Pharmacodynamics of Antimicrobials in Japan: Importance of the Promotion of Population PK/PD Analysis

Kensuke Shoji, Jumpei Saito, Hidefumi Nakamura, Kazuaki Matsumoto, Kazutaka Oda, Yoshio Takesue, Isao Miyairi

研究成果: Review article査読

抄録

Pharmacologic knowledge is important for pediatricians conducting feasible pharmacokinetic or pharmacodynamic (PK/PD) studies or applying effective antimicrobial therapies in children. Because of the difficulties in conducting PK/PD studies in children, antimicrobial PK/PD data in children are still limited. To fill in the lack of knowledge, promotion of population PK/PD analysis, which allows us to handle sparse sampling data from individual patients, is important because it is considered a suitable methodology to conduct PK/PD studies in children with limited blood drug concentration data for PK/PD analysis. Population PK/PD analysis is also useful in the clinical setting to provide individualized optimal dosage for each patient with various conditions. Here we summarized the current aspects of pediatric PK/PD studies of antimicrobials in Japan from clinical and research perspectives, specifically focusing on the importance of population PK/PD analysis.

本文言語English
ページ(範囲)E418-E423
ジャーナルPediatric Infectious Disease Journal
41
10
DOI
出版ステータスPublished - 2022 10月 1

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 微生物学(医療)
  • 感染症

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