Current role of liver transplantation for methylmalonic acidemia: A review of the literature

Mureo Kasahara, Reiko Horikawa, Manabu Tagawa, Shinji Uemoto, Satoshi Yokoyama, Yumiko Shibata, Takafumi Kawano, Tatsuo Kuroda, Toshiro Honna, Koichi Tanaka, Morihiro Saeki

研究成果: Article査読

77 被引用数 (Scopus)

抄録

To evaluate the current role of liver transplantation (LT) for methylmalonic acidemia (MMA), we reviewed the literature on outcomes of this treatment, and describe three of our own cases of living-donor liver transplantation (LDLT). The total number of LT cases identified was 18. Transplantation mode was deceased donor LT in 12, including five combined liver-kidney transplantations (CLKT) from deceased donors, and LDLT in six. Three hospital mortalities were noted, because of metabolic decompensation, sepsis and aspergillosis. Although mean postoperative serum MMA level decreased to 13.8% ± 9.2% (range 1.25-26.1%) of preoperative levels, four patients (22.2%) had renal insufficiency after isolated LT and three (16.7%) had postoperative neurological disability. Continuing metabolic damage to the kidney and brain may occur even after successful LT. Further evaluation is required to determine the long-term suitability of this treatment modality.

本文言語English
ページ(範囲)943-947
ページ数5
ジャーナルPediatric Transplantation
10
8
DOI
出版ステータスPublished - 2006 12月
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 移植

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