Current topics in pheochromocytoma

K. Nakao, H. Itoh, K. Takaya

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Pheochromocytoma is the tumor that produces catecholamines and originates from chromaffin cells, which are differentiated from sympathoadrenal progenitor cells of neural crest under the influence of glucocorticoids. Genetic abnormalities of familial pheochromocytomas have elucidated oncogenic genetic bases of the tumor, including gene abnormalities of the RET proto-oncogene in multiple endocrine neoplasia type 2, VHL gene in von Hippel Lindau's disease or the NFI gene in neurofibromatosis. Co- localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomullin, which is the recently identified vasodepressor peptide elevating cAMP production, isrecognized. The significance of these substances in modulating clinical features of pheochromocytomas is not fully understood. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

本文言語English
ページ(範囲)124s-128s
ジャーナルBiomedicine and Pharmacotherapy
54
SUPPL. 1
DOI
出版ステータスPublished - 2000 6
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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