Current View: Intestinal Stem Cells and Signaling

David H. Scoville, Toshiro Sato, Xi C. He, Linheng Li

研究成果: Article

293 引用 (Scopus)

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Studies using mice have yielded significant amounts of information regarding signaling pathways, such as Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch, involved in intestinal development and homeostasis, including stem cell regulation and lineage specification and maturation. However, attempts to model signals definitively that control intestinal stem cells have been difficult because of a long-standing and recently reenergized debate surrounding their location. Although crypt-based columnar cells have been recently shown to display self-renewal and multipotential capacity, a large body of evidence supports long-term label-retaining cells, located on average at the +4 position just above the Paneth cells, as putative stem cells. Herein, we propose that both these cell types represent true intestinal stem cells maintained in different states (quiescent vs actively cycling), presumably via interactions with different microenvironments. Finally, we review current findings regarding the roles of Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch pathways within the intestine.

元の言語English
ページ(範囲)849-864
ページ数16
ジャーナルGastroenterology
134
発行部数3
DOI
出版物ステータスPublished - 2008 3
外部発表Yes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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