Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: Towards vascular self assembly in microchannels

Tadahiro Yamashita, P. Kollmannsberger, K. Mawatari, V. Vogel, T. Kitamori

研究成果: Conference contribution

3 引用 (Scopus)

抄録

A new model is proposed which describes the spontaneous detachment of vascular smooth muscle cells induced by surface curvature. Growing tubular structures from smooth muscle cells (SMCs) in vitro is a key challenge in microvascular tissue engineering. SMC growth is however significantly suppressed on curved substrates. We show that this is caused by mechanical interaction between adhering cells and the surrounding geometry, which compromises the adhesion of growing tissue. Our model opens up new strategies for engineering luminal vasculature in microdevices, and gives new insights for controlling tissue formation in micro environments.

元の言語English
ホスト出版物のタイトル17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
出版者Chemical and Biological Microsystems Society
ページ2022-2024
ページ数3
3
ISBN(印刷物)9781632666246
出版物ステータスPublished - 2013 1 1
外部発表Yes
イベント17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
継続期間: 2013 10 272013 10 31

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Germany
Freiburg
期間13/10/2713/10/31

Fingerprint

Microchannels
Self assembly
Muscle
Cells
Tissue
Cell growth
Tissue engineering
Adhesion
Geometry
Substrates

ASJC Scopus subject areas

  • Bioengineering

これを引用

Yamashita, T., Kollmannsberger, P., Mawatari, K., Vogel, V., & Kitamori, T. (2013). Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: Towards vascular self assembly in microchannels. : 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (巻 3, pp. 2022-2024). Chemical and Biological Microsystems Society.

Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets : Towards vascular self assembly in microchannels. / Yamashita, Tadahiro; Kollmannsberger, P.; Mawatari, K.; Vogel, V.; Kitamori, T.

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 巻 3 Chemical and Biological Microsystems Society, 2013. p. 2022-2024.

研究成果: Conference contribution

Yamashita, T, Kollmannsberger, P, Mawatari, K, Vogel, V & Kitamori, T 2013, Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: Towards vascular self assembly in microchannels. : 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 巻. 3, Chemical and Biological Microsystems Society, pp. 2022-2024, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 13/10/27.
Yamashita T, Kollmannsberger P, Mawatari K, Vogel V, Kitamori T. Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: Towards vascular self assembly in microchannels. : 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 巻 3. Chemical and Biological Microsystems Society. 2013. p. 2022-2024
Yamashita, Tadahiro ; Kollmannsberger, P. ; Mawatari, K. ; Vogel, V. ; Kitamori, T. / Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets : Towards vascular self assembly in microchannels. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 巻 3 Chemical and Biological Microsystems Society, 2013. pp. 2022-2024
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