Curvature-induced spontaneous detachment of vascular smooth muscle cell sheets: Towards vascular self assembly in microchannels

T. Yamashita, P. Kollmannsberger, K. Mawatari, V. Vogel, T. Kitamori

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

A new model is proposed which describes the spontaneous detachment of vascular smooth muscle cells induced by surface curvature. Growing tubular structures from smooth muscle cells (SMCs) in vitro is a key challenge in microvascular tissue engineering. SMC growth is however significantly suppressed on curved substrates. We show that this is caused by mechanical interaction between adhering cells and the surrounding geometry, which compromises the adhesion of growing tissue. Our model opens up new strategies for engineering luminal vasculature in microdevices, and gives new insights for controlling tissue formation in micro environments.

本文言語English
ホスト出版物のタイトル17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
出版社Chemical and Biological Microsystems Society
ページ2022-2024
ページ数3
ISBN(印刷版)9781632666246
出版ステータスPublished - 2013 1 1
外部発表はい
イベント17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
継続期間: 2013 10 272013 10 31

出版物シリーズ

名前17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
3

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
国/地域Germany
CityFreiburg
Period13/10/2713/10/31

ASJC Scopus subject areas

  • バイオエンジニアリング

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