The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.
|ジャーナル||Journal of the Chemical Society, Chemical Communications|
|出版ステータス||Published - 1993 12 1|
ASJC Scopus subject areas
- Molecular Medicine