Cycloaromatization and DNA cleavage of novel enyne-allene systems

Kazunobu Toshima; Kazumi Ohta; Atsuo Ohtsuka; Shuichi Matsumura; Masaya Nakata

doi:10.1039/C39930001406

Cycloaromatization and DNA cleavage of novel enyne-allene systems

Kazunobu Toshima, Kazumi Ohta, Atsuo Ohtsuka, Shuichi Matsumura, Masaya Nakata

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研究成果: Article › 査読

36 被引用数 (Scopus)

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The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.

本文言語	English
ページ（範囲）	1406-1407
ページ数	2
ジャーナル	Journal of the Chemical Society, Chemical Communications
号	18
DOI	https://doi.org/10.1039/C39930001406
出版ステータス	Published - 1993 12月 1

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分子医療

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AU - Nakata, Masaya

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Cycloaromatization and DNA cleavage of novel enyne-allene systems

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