Cycloaromatization and DNA cleavage of novel enyne-allene systems

Kazunobu Toshima, Kazumi Ohta, Atsuo Ohtsuka, Shuichi Matsumura, Masaya Nakata

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) via the allene-ene-cumulene intermediate 10 and showed DNA-cleaving activities under basic conditions without any additive.

本文言語English
ページ(範囲)1406-1407
ページ数2
ジャーナルJournal of the Chemical Society, Chemical Communications
18
DOI
出版ステータスPublished - 1993 12 1

ASJC Scopus subject areas

  • Molecular Medicine

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