Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata

Takuhito Ohse, Shigeru Ohba, Takashi Yamamoto, Takashi Koyano, Kazuo Umezawa

研究成果: Article査読

67 被引用数 (Scopus)

抄録

In the course of screening for Ras function inhibitors, rocaglaol (1) and the related compounds, the known pyrimidinone (2) and the novel aglaiastatin (3), were isolated from a CHCl3 extract of the leaves of Aglaia odorata. The structure of 3 was elucidated as a novel cyclopentabenzofuran on the basis of its NMR spectroscopic data and by X-ray crystallographic analysis. These compounds (1-3) were potent inhibitors of the growth of K-ras-NRK cells, with IC50 values of 1-10 ng/mL, and induced normal morphology in K-ras-NRK cells at 10-30 ng/mL. They also specifically inhibited protein synthesis. Aglaiastatin (3) was slightly more potent than 1 and 2 in inhibiting cell growth. Aglaiastatin (3) reduced the amount of Ras, possibly by inhibiting its de novo synthesis.

本文言語English
ページ(範囲)650-652
ページ数3
ジャーナルJournal of Natural Products
59
7
DOI
出版ステータスPublished - 1996 7月

ASJC Scopus subject areas

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

フィンガープリント

「Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル