Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain

Hiroshi Inoue, Shinichi Kohsaka, Kazunari Yoshida, Mitsuhiro Ohtani, Shigeo Toya, Yasuzo Tsukada

研究成果: Article査読

80 被引用数 (Scopus)

抄録

The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.

本文言語English
ページ(範囲)85-90
ページ数6
ジャーナルNeuroscience Letters
54
1
DOI
出版ステータスPublished - 1985 1 1

ASJC Scopus subject areas

  • 神経科学(全般)

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