[Cytokines in bone diseases. Osteoprotegerin and juvenile Paget's disease].

Naobumi Hosogane, Takeshi Miyamoto

研究成果: Review article査読

抄録

Juvenile Paget's disease (JPD) is a rare autosomal-recessive hereditary disease and is typically diagnosed in infants or young children. JPD causes bone pain, bone expansion and deformity, and severity generally increases during adolescence. Recently, differentiation and maturation of osteoclasts, controlled by RANK, which is expressed in osteoclast precursors and its ligand, RANKL, which is expressed in osteoblasts or marrow stromal cells, have been clarified. Recent studies elucidated that JPD was caused by mutation of TNFRSF11B, which encodes osteoprotegerin, a soluble decoy receptor of RANKL. We summarize the outline and etiology of JPD.

本文言語English
ページ(範囲)1540-1544
ページ数5
ジャーナルClinical calcium
20
10
出版ステータスPublished - 2010 10月

ASJC Scopus subject areas

  • 医学(全般)

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