Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi; Yumi Fukao; Takuro Maruyama; Tohru Obata; Motohiro Tanaka; Takuma Sasaki; Masayuki Mirage; Mohammad Ekramul Haque; Yoshisuke Tsuda

doi:10.1248/cpb.46.528

Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi, Yumi Fukao, Takuro Maruyama, Tohru Obata, Motohiro Tanaka, Takuma Sasaki, Masayuki Mirage, Mohammad Ekramul Haque, Yoshisuke Tsuda

研究成果: Article › 査読

53 被引用数 (Scopus)

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Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.

本文言語	English
ページ（範囲）	528-530
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	46
号	3
DOI	https://doi.org/10.1248/cpb.46.528
出版ステータス	Published - 1998
外部発表	はい

ASJC Scopus subject areas

化学 (全般)
創薬

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10.1248/cpb.46.528

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AU - Kiuchi, Fumiyuki

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AU - Obata, Tohru

AU - Tanaka, Motohiro

AU - Sasaki, Takuma

AU - Mirage, Masayuki

AU - Haque, Mohammad Ekramul

AU - Tsuda, Yoshisuke

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Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

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