Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Kiyoyuki Yamada; Makoto Ojika; Hideo Kigoshi; Kiyotake Suenaga

doi:10.2183/pjab.86.176

Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

Kiyoyuki Yamada, Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga

化学科

研究成果: Review article › 査読

22 被引用数 (Scopus)

抄録

From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

本文言語	English
ページ（範囲）	176-189
ページ数	14
ジャーナル	Proceedings of the Japan Academy Series B: Physical and Biological Sciences
巻	86
号	3
DOI	https://doi.org/10.2183/pjab.86.176
出版ステータス	Published - 2010 3月

ASJC Scopus subject areas

農業および生物科学（全般）
物理学および天文学（全般）

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10.2183/pjab.86.176

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abstract = "From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.",

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AU - Yamada, Kiyoyuki

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AU - Kigoshi, Hideo

AU - Suenaga, Kiyotake

PY - 2010/3

Y1 - 2010/3

N2 - From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

AB - From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

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KW - Chemical structure

KW - Chemical synthesis

KW - Cytotoxic substances

KW - Isolation

KW - Sea hare

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JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

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Cytotoxic substances from two species of Japanese sea hares: Chemistry and bioactivity

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