Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

Kiyotake Suenaga, Noriyuki Kamei, Youko Okugawa, Masaki Takagi, Atsushi Akao, Hideo Kigoshi, Kiyoyuki Yamada

研究成果: Article

46 引用 (Scopus)

抜粋

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

元の言語English
ページ(範囲)269-274
ページ数6
ジャーナルBioorganic and Medicinal Chemistry Letters
7
発行部数3
DOI
出版物ステータスPublished - 1997 2 4
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

フィンガープリント Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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