Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells

Taiko Oda, Noriko Ikeda, Shoko Nakashima, Yoshihiro Sato

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Recently, we investigated the inhibitory effects of 17β-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.

本文言語English
ページ(範囲)75-82
ページ数8
ジャーナルDrug and Chemical Toxicology
25
1
DOI
出版ステータスPublished - 2002 2 18

ASJC Scopus subject areas

  • 毒物学
  • 薬理学
  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発
  • 化学的な安全衛生

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