Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, against human solid-tumor-derived cell lines

Taiko Oda, Keiichi Kamoshita, Sakiko Maruyama, Kuniko Masuda, Masakazu Nishimoto, Jinzhong Xu, Kazuyo Ukai, Remy Emile Petrus Mangindaan, Michio Namikoshi

研究成果: Article査読

22 被引用数 (Scopus)

抄録

The in vitro growth inhibitory activity of lissoclibadins and lissoclinotoxins isolated from the tropical ascidian Lissoclinum cf. badium against nine human cancer cell lines was examined to evaluate their potential anticancer efficacy. Lissoclibadins 1 (1) and 2 (2), and lissoclinotoxin F (4) showed the strongest activity of the six compounds tested, which were more potent than the anticancer drug cisplatin. Compound 1 has a trimeric structure, and compounds 2 and 4 are structural isomers possessing dimeric structures connected by disulfide and sulfide bonds of trans- and cis-orientations, respectively. Lissoclibadin 3 (3), a dimeric compound connected by two sulfide bonds, and two monomeric compounds (5, 6) were less active than 1, 2, and 4. Lissoclibadin 2 (2) was the most interesting compound possessing potent inhibitory activity against colon (DLD-1 and HCT116), breast (MDA-MB-231), renal (ACHN), and non-small-cell lung (NCI-H460) cancer cell lines and showing no toxicity following a 50 mg/kg single treatment to mice, and preferable stability in rat plasma.

本文言語English
ページ(範囲)385-387
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
30
2
DOI
出版ステータスPublished - 2007 2

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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