Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

Kazuhisa Sugai, Tomoyoshi Tamura, Motoaki Sano, Shizuka Uemura, Masahiko Fujisawa, Yoshinori Katsumata, Jin Endo, Joe Yoshizawa, Koichiro Homma, Masaru Suzuki, Eiji Kobayashi, Junichi Sasaki, Yoji Hakamata

研究成果: Article査読

抄録

A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.

本文言語English
論文番号20173
ジャーナルScientific reports
10
1
DOI
出版ステータスPublished - 2020 12

ASJC Scopus subject areas

  • 一般

フィンガープリント

「Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル