DAMPs (damage-associated molecular patterns) and inflammation

Hiroaki Ooboshi, Takashi Shichita

研究成果: Review article査読

9 被引用数 (Scopus)

抄録

Post-ischemic inflammation is re-appraised as an important player in the progression of ischemic stroke. Activation of inflammatory cells via Toll-like receptor 2 (TLR2) and TLR4 is caused by several damage-associated molecular patterns (DAMPs), including high mobility group box-1 (HMGB-1) and heat shock proteins. We have recently found that peroxiredoxin (Prx) is one of the strong DAMPs and activates infiltrating macrophages in brain ischemia. We have also found that interleukin-23 (IL-23) from the activated macrophages stimulates γδT cells which release IL-17, thereby causing the delayed expansion of infarct lesions. Further investigation of the innate immune response would lead to development of novel stroke treatment with a broad therapeutic time window.

本文言語English
ページ(範囲)573-578
ページ数6
ジャーナルNihon rinsho. Japanese journal of clinical medicine
74
4
出版ステータスPublished - 2016 4月 1
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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