De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

Michihide Tokuhira, Reiko Watanabe, Atsushi Iizuka, Yasunobu Sekiguchi, Tomoe Nemoto, Kyoto Hanzawa, Ichiro Takamatsu, Taro Maruyama, Jun Ichi Tamaru, Shinji Itoyama, Hiroshi Suzuki, Tsutomu Takeuchi, Shigehisa Mori

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.

本文言語English
ページ(範囲)162-167
ページ数6
ジャーナルAmerican journal of hematology
82
2
DOI
出版ステータスPublished - 2007 2
外部発表はい

ASJC Scopus subject areas

  • 血液学

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