Decarboxylation and Racemization of Unnatural Compounds Using Artificial Enzymes Derived from Arylmalonate Decarboxylase

研究成果: Chapter

抄録

Protein engineering has emerged as a powerful tool for engineering enzymes with new functions. We have been investigating an arylmalonate decarboxylase that acts on unnatural arylmalonates to give (R)-α-arylpropionates (profens). This chapter evaluates the potential use of directed evolution and rational design in completely changing the function of the decarboxylase to an artificial racemase and (S)-selective decarboxylase. The variants are useful biocatalysts for producing optically active profens.

本文言語English
ホスト出版物のタイトルGreen Biocatalysis
出版社wiley
ページ59-70
ページ数12
ISBN(電子版)9781118828083
ISBN(印刷版)9781118822296
DOI
出版ステータスPublished - 2016 5 13

ASJC Scopus subject areas

  • 工学(全般)
  • 化学工学(全般)

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