Decarboxylative Intramolecular Cyclization and Sequential Halogenation of Cyclic Enol Carbonates ®Synthesis of Stereochemically-defined Seven-membered Carbocycles®

Haruki Yokoyama, Natsuki Kimaru, Akane Kozuma, Keiichi Komatsuki, Tohru Yamada, Kodai Saito

研究成果: Article査読

抄録

The intramolecular cyclization for the construction of 7-membered carbocycles triggered by the decarboxylation of a cyclic enol carbonate was studied. In this study, it was found that the treatment of the alkene-tethered cyclic enol carbonate with a metal halide resulted in the decarboxylation and sequential intramolecular cyclization, followed by halogenation to give a functionalized 7-membered ketone with high stereoselectivity. Among the Lewis acidic metal halides, titanium tetrachloride was the most effective for this transformation. This method was applicable for a variety of substrates.

本文言語English
ページ(範囲)867-869
ページ数3
ジャーナルChemistry Letters
51
8
DOI
出版ステータスPublished - 2022 8月

ASJC Scopus subject areas

  • 化学 (全般)

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