Decarboxylative Nazarov Cyclization-Based Chirality Transfer for Asymmetric Synthesis of 2-Cyclopentenones

Keiichi Komatsuki, Akane Kozuma, Kodai Saito, Tohru Yamada

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Asymmetric synthesis of 2-cyclopentenones was achieved by chirality transfer based on Lewis acid catalyzed decarboxylative Nazarov cyclization of optically active cyclic enol carbonates, which are prepared by silver-catalyzed carbon dioxide incorporation into optically pure propargyl alcohols. The stereochemistry at the 4,5-positions of the 2-cyclopentenones was cleanly constructed by reflecting the stereochemistry of the starting materials. This method could be applied to various substrates to obtain the corresponding products in high yields with highly efficient chirality transfer.

本文言語English
ページ(範囲)6628-6632
ページ数5
ジャーナルOrganic Letters
21
17
DOI
出版ステータスPublished - 2019 9 6

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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