Decrease by psychotropic drugs and local anaesthetics of membrane fluidity measured by fluorescence anisotropy in Escherichia coli

K. Tanji, Y. Ohta, S. Kawato, T. Mizushima, S. Natori, K. Sekimizu

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The effects of psychotropic drugs and local anaesthetics on the fluidity of Escherichia coli cell membranes were examined. Chlorpromazine was shown to increase 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy, indicating that it decreased the membrane fluidity. This increase was significant at a temperature of more than 24°C. Dibucaine, lignocaine, imipramine, tetracaine and procaine also increased the fluorescence anisotropy.

本文言語English
ページ(範囲)1036-1037
ページ数2
ジャーナルJournal of Pharmacy and Pharmacology
44
12
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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