Decrease in expression of the master operon of flagellin synthesis in a dnaA46 mutant of Escherichia coli

Tohru Mizushima, Rimiko Koyanagi, Tsutomu Katayama, Takeyoshi Miki, Kazuhisa Sekimizu

研究成果: Article査読

14 被引用数 (Scopus)

抄録

We examined the expression of the fliC, fliA and flhD genes in the dnaA46 mutant. In Northern blot analysis, the amounts of fliC, fliA, and flhD mRNA decreased in the dnaA46 mutant growing at 37°C but not at 28 °C. The promoter activity of each gene also decreased in this mutant at 37°C, but not at 28°C. The decrease in expression of the flhD gene was not related to the cAMP-catabolite activator protein (CAP) pathway. We tentatively conclude that DnaA protein is involved in the expression of the flhD gene by a mechanism independent of the cAMP-CAP pathway.

本文言語English
ページ(範囲)327-331
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
20
4
DOI
出版ステータスPublished - 1997 4

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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