Decrease in vascular endothelial growth factor expression area in islets may be associated with type 2 diabetes development

Yoshihiro Takamiya, Yoichi Oikawa, Taketo Yamada, Akira Shimada, Hiroshi Itoh

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Aims: Animal studies have demonstrated that decreased vessel density in islets due to reduced expression of islet vascular endothelial growth factor (VEGF) may lead to impaired insulin secretion from β-cells, possibly contributing to type 2 diabetes development. However, no study has demonstrated an association between VEGF expression and vessel density in islets in human subjects with type 2 diabetes. The aim of this study was to evaluate the role of VEGF expression in islets in type 2 diabetes development, using human pancreatic tissue. Methods: We collected pancreatic tissue at autopsy from type 2 diabetic subjects (n = 13) and age- and sex-matched nondiabetic subjects (n = 13) under 80 years old, and investigated VEGF expression area and vessel density in islets by immunohistochemical staining. Results: In comparison with nondiabetic subjects, type 2 diabetic subjects showed a decrease in both islet VEGF expression area and islet vessel density, which were positively correlated in all subjects examined and in type 2 diabetic subjects. Conclusions: Decreased islet VEGF expression may be associated with the decrease in islet vessel volume, which probably contributes to type 2 diabetes development due to impaired insulin secretion from β-cells.

本文言語English
ページ(範囲)202-208
ページ数7
ジャーナルDiabetology International
3
4
DOI
出版ステータスPublished - 2012 12月 1

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学

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