Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA

Y. Sugimoto, I. B. Roninson, T. Tsuruo

研究成果: Article

36 引用 (Scopus)

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Amplification and increased expression of the mdr1 gene associated with multidrug resistance in human tumors were found in multidrug-resistant sublines of human myelogenous leukemia K562 selected with vincristine (K562/VCR) or adriamycin (K562/ADM). In two revertant cell lines of K562/ADM, amplification of the mdr1 gene was maintained at the same level as in K562/ADM, but expression of the 4,5-kilobase mdr1 mRNA was greatly decreased, indicating that amplified genes may be inactivated at the level of transcription without a corresponding loss of amplified DNA.

元の言語English
ページ(範囲)4549-4552
ページ数4
ジャーナルMolecular and Cellular Biology
7
発行部数12
DOI
出版物ステータスPublished - 1987 1 1
外部発表Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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