Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Akihito Hishikawa, Kaori Hayashi, Takaya Abe, Mari Kaneko, Hideki Yokoi, Tatsuhiko Azegami, Mari Nakamura, Norifumi Yoshimoto, Takeshi Kanda, Yusuke Sakamaki, Hiroshi Itoh

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

本文言語English
ページ(範囲)1318-1332.e4
ジャーナルCell Reports
26
5
DOI
出版ステータスPublished - 2019 1 29

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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「Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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