Decreased plasma histidine level predicts risk of relapse in patients with ulcerative colitis in remission

Tadakazu Hisamatsu, Nobukazu Ono, Akira Imaizumi, Maiko Mori, Hiroaki Suzuki, Michihide Uo, Masaki Hashimoto, Makoto Naganuma, Katsuyoshi Matsuoka, Shinta Mizuno, Mina T. Kitazume, Tomoharu Yajima, Haruhiko Ogata, Yasushi Iwao, Toshifumi Hibi, Takanori Kanai

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Patients with UC have repeated remission and relapse. Clinical biomarkers that can predict relapse in UC patients in remission have not been identified. To facilitate the prediction of relapse of UC, we investigated the potential of novel multivariate indexes using statistical modeling of plasma free amino acid (PFAA) concentrations. We measured fasting PFAA concentrations in 369 UC patients in clinical remission, and 355 were observed prospectively for up to 1 year. Relapse rate within 1 year was 23% (82 of 355 patients). The age-and genderadjusted hazard ratio for the lowest quartile compared with the highest quartile of plasma histidine concentration was 2.55 (95% confidence interval: 1.41-4.62; p = 0.0020 (logrank), p for trend = 0.0005). We demonstrated that plasma amino acid profiles in UC patients in clinical remission can predict the risk of relapse within 1 year. Decreased histidine level in PFAAs was associated with increased risk of relapse. Metabolomics could be promising for the establishment of a non-invasive predictive marker in inflammatory bowel disease.

本文言語English
論文番号e0140716
ジャーナルPloS one
10
10
DOI
出版ステータスPublished - 2015 10 16

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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