Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids

O. Yoshino, T. Hayashi, Y. Osuga, M. Orisaka, H. Asada, Shigeo Okuda, M. Hori, M. Furuya, H. Onuki, Y. Sadoshima, H. Hiroi, T. Fujiwara, F. Kotsuji, Y. Yoshimura, O. Nishii, Y. Taketani

研究成果: Article

71 引用 (Scopus)

抄録

BACKGROUND: The relationship between fibroids and infertility remains an unsolved question, and management of intramural fibroids is controversial. During the implantation phase, uterine peristalsis is dramatically reduced, which is thought to facilitate embryo implantation. Our aims were to evaluate (i) the occurrence and frequency of uterine peristalsis in infertile women with intramural fibroids and (ii) whether the presence of uterine peristalsis decreases the pregnancy rate. METHODS: Ninety-five infertile patients with uterine fibroids were examined using magnetic resonance imaging (MRI). Inclusion criteria were as follows: (i) presence of intramural fibroids, excluding submucosal type; (ii) no other significant infertility factors (excluding endometriosis); and (iii) regular menstrual cycles, and MRI performed at the time of implantation (luteal phase day 5-9). The frequency of junctional zone movement was evaluated using cine-mode-display MRI. After MRI, patients underwent infertility treatment for up to 4 months, and the pregnancy rate was evaluated prospectively. RESULTS: Fifty-one patients fulfilled the inclusion criteria, and 29 (57) and 22 (43) patients were assigned to the low (0 or 1 time/3 min) or high frequency (≥2 times/3 min) uterine peristalsis group, respectively. Endometriosis incidence was the same in both groups. Ten out of the 29 patients (34) in the low-frequency group achieved pregnancy, compared with none of the 22 patients (0) in the high-frequency group (P< 0.005). Comparing pregnant and non-pregnant cases, 4 of 10 patients (40) and 9 of 41 patients (22), respectively, had endometriosis (not significant). CONCLUSIONS: A higher frequency of uterine peristalsis during the mid-luteal phase might be one of the causes of infertility associated with intramural-type fibroids.

元の言語English
ページ(範囲)2475-2479
ページ数5
ジャーナルHuman Reproduction
25
発行部数10
DOI
出版物ステータスPublished - 2010 10

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Peristalsis
Leiomyoma
Pregnancy Rate
Infertility
Endometriosis
Magnetic Resonance Imaging
Luteal Phase
Menstrual Cycle
Pregnancy
Incidence

ASJC Scopus subject areas

  • Rehabilitation
  • Obstetrics and Gynaecology
  • Reproductive Medicine

これを引用

Yoshino, O., Hayashi, T., Osuga, Y., Orisaka, M., Asada, H., Okuda, S., ... Taketani, Y. (2010). Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids. Human Reproduction, 25(10), 2475-2479. https://doi.org/10.1093/humrep/deq222

Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids. / Yoshino, O.; Hayashi, T.; Osuga, Y.; Orisaka, M.; Asada, H.; Okuda, Shigeo; Hori, M.; Furuya, M.; Onuki, H.; Sadoshima, Y.; Hiroi, H.; Fujiwara, T.; Kotsuji, F.; Yoshimura, Y.; Nishii, O.; Taketani, Y.

:: Human Reproduction, 巻 25, 番号 10, 10.2010, p. 2475-2479.

研究成果: Article

Yoshino, O, Hayashi, T, Osuga, Y, Orisaka, M, Asada, H, Okuda, S, Hori, M, Furuya, M, Onuki, H, Sadoshima, Y, Hiroi, H, Fujiwara, T, Kotsuji, F, Yoshimura, Y, Nishii, O & Taketani, Y 2010, 'Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids', Human Reproduction, 巻. 25, 番号 10, pp. 2475-2479. https://doi.org/10.1093/humrep/deq222
Yoshino, O. ; Hayashi, T. ; Osuga, Y. ; Orisaka, M. ; Asada, H. ; Okuda, Shigeo ; Hori, M. ; Furuya, M. ; Onuki, H. ; Sadoshima, Y. ; Hiroi, H. ; Fujiwara, T. ; Kotsuji, F. ; Yoshimura, Y. ; Nishii, O. ; Taketani, Y. / Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids. :: Human Reproduction. 2010 ; 巻 25, 番号 10. pp. 2475-2479.
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abstract = "BACKGROUND: The relationship between fibroids and infertility remains an unsolved question, and management of intramural fibroids is controversial. During the implantation phase, uterine peristalsis is dramatically reduced, which is thought to facilitate embryo implantation. Our aims were to evaluate (i) the occurrence and frequency of uterine peristalsis in infertile women with intramural fibroids and (ii) whether the presence of uterine peristalsis decreases the pregnancy rate. METHODS: Ninety-five infertile patients with uterine fibroids were examined using magnetic resonance imaging (MRI). Inclusion criteria were as follows: (i) presence of intramural fibroids, excluding submucosal type; (ii) no other significant infertility factors (excluding endometriosis); and (iii) regular menstrual cycles, and MRI performed at the time of implantation (luteal phase day 5-9). The frequency of junctional zone movement was evaluated using cine-mode-display MRI. After MRI, patients underwent infertility treatment for up to 4 months, and the pregnancy rate was evaluated prospectively. RESULTS: Fifty-one patients fulfilled the inclusion criteria, and 29 (57) and 22 (43) patients were assigned to the low (0 or 1 time/3 min) or high frequency (≥2 times/3 min) uterine peristalsis group, respectively. Endometriosis incidence was the same in both groups. Ten out of the 29 patients (34) in the low-frequency group achieved pregnancy, compared with none of the 22 patients (0) in the high-frequency group (P< 0.005). Comparing pregnant and non-pregnant cases, 4 of 10 patients (40) and 9 of 41 patients (22), respectively, had endometriosis (not significant). CONCLUSIONS: A higher frequency of uterine peristalsis during the mid-luteal phase might be one of the causes of infertility associated with intramural-type fibroids.",
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AU - Yoshino, O.

AU - Hayashi, T.

AU - Osuga, Y.

AU - Orisaka, M.

AU - Asada, H.

AU - Okuda, Shigeo

AU - Hori, M.

AU - Furuya, M.

AU - Onuki, H.

AU - Sadoshima, Y.

AU - Hiroi, H.

AU - Fujiwara, T.

AU - Kotsuji, F.

AU - Yoshimura, Y.

AU - Nishii, O.

AU - Taketani, Y.

PY - 2010/10

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N2 - BACKGROUND: The relationship between fibroids and infertility remains an unsolved question, and management of intramural fibroids is controversial. During the implantation phase, uterine peristalsis is dramatically reduced, which is thought to facilitate embryo implantation. Our aims were to evaluate (i) the occurrence and frequency of uterine peristalsis in infertile women with intramural fibroids and (ii) whether the presence of uterine peristalsis decreases the pregnancy rate. METHODS: Ninety-five infertile patients with uterine fibroids were examined using magnetic resonance imaging (MRI). Inclusion criteria were as follows: (i) presence of intramural fibroids, excluding submucosal type; (ii) no other significant infertility factors (excluding endometriosis); and (iii) regular menstrual cycles, and MRI performed at the time of implantation (luteal phase day 5-9). The frequency of junctional zone movement was evaluated using cine-mode-display MRI. After MRI, patients underwent infertility treatment for up to 4 months, and the pregnancy rate was evaluated prospectively. RESULTS: Fifty-one patients fulfilled the inclusion criteria, and 29 (57) and 22 (43) patients were assigned to the low (0 or 1 time/3 min) or high frequency (≥2 times/3 min) uterine peristalsis group, respectively. Endometriosis incidence was the same in both groups. Ten out of the 29 patients (34) in the low-frequency group achieved pregnancy, compared with none of the 22 patients (0) in the high-frequency group (P< 0.005). Comparing pregnant and non-pregnant cases, 4 of 10 patients (40) and 9 of 41 patients (22), respectively, had endometriosis (not significant). CONCLUSIONS: A higher frequency of uterine peristalsis during the mid-luteal phase might be one of the causes of infertility associated with intramural-type fibroids.

AB - BACKGROUND: The relationship between fibroids and infertility remains an unsolved question, and management of intramural fibroids is controversial. During the implantation phase, uterine peristalsis is dramatically reduced, which is thought to facilitate embryo implantation. Our aims were to evaluate (i) the occurrence and frequency of uterine peristalsis in infertile women with intramural fibroids and (ii) whether the presence of uterine peristalsis decreases the pregnancy rate. METHODS: Ninety-five infertile patients with uterine fibroids were examined using magnetic resonance imaging (MRI). Inclusion criteria were as follows: (i) presence of intramural fibroids, excluding submucosal type; (ii) no other significant infertility factors (excluding endometriosis); and (iii) regular menstrual cycles, and MRI performed at the time of implantation (luteal phase day 5-9). The frequency of junctional zone movement was evaluated using cine-mode-display MRI. After MRI, patients underwent infertility treatment for up to 4 months, and the pregnancy rate was evaluated prospectively. RESULTS: Fifty-one patients fulfilled the inclusion criteria, and 29 (57) and 22 (43) patients were assigned to the low (0 or 1 time/3 min) or high frequency (≥2 times/3 min) uterine peristalsis group, respectively. Endometriosis incidence was the same in both groups. Ten out of the 29 patients (34) in the low-frequency group achieved pregnancy, compared with none of the 22 patients (0) in the high-frequency group (P< 0.005). Comparing pregnant and non-pregnant cases, 4 of 10 patients (40) and 9 of 41 patients (22), respectively, had endometriosis (not significant). CONCLUSIONS: A higher frequency of uterine peristalsis during the mid-luteal phase might be one of the causes of infertility associated with intramural-type fibroids.

KW - cine magnetic resonance imaging

KW - infertility

KW - intramural fibroids

KW - uterine fibroma

KW - uterine peristalsis

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