Deep infection in tumor endoprosthesis around the knee: A multi-institutional study by the Japanese musculoskeletal oncology group

Takeshi Morii, Hideo Morioka, Takafumi Ueda, Nobuhito Araki, Nobuyuki Hashimoto, Akira Kawai, Kazuo Mochizuki, Shoichi Ichimura

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Background: The incidence of endoprosthesis failure has been well studied, but few studies have described the clinical characteristics of deep infection in tumor prostheses. This study aimed to analyze the characteristics of deep infection in tumor endoprostheses around the knee. Methods. We analyzed clinical data of 57 patients with deep infections involving tumor endoprostheses around the knee enrolled from the Japanese Musculoskeletal Oncology Group. Profile of clinical presentation including time between surgery and infection, initial symptoms/blood tests and microbial cultures was evaluated. In addition pre-, intra-, and postoperative clinical factors influencing clinical presentation and treatment outcomes of infections were analyzed. Results: Mean interval between the initial operation and diagnosis was 13months, and mean time required for infection control was 12months. The most common pathogen was Staphylococcus. Infection control rates were significantly higher when prostheses were removed rather than salvaged. Ten-year prosthesis survival and limb salvage rates were 41.6% and 75.6%, respectively. Analysis of underlying clinical factors suggested that soft-tissue condition significantly influenced the duration of the infection control period and likelihood of limb salvage. Conclusions: Infection control is a prolonged process. Deep infection frequently results in amputation or prosthesis loss. Intensive analysis of clinical characteristics may aid infection control.

本文言語English
論文番号51
ジャーナルBMC Musculoskeletal Disorders
14
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

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