Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice

S. H. Fatemi, E. S. Emamian, D. Kist, R. W. Sidwell, K. Nakajima, P. Akhter, A. Shier, S. Sheikh, K. Bailey

研究成果: Article

206 引用 (Scopus)

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Recent reports indicate an association between second trimester human influenza viral infection and later development of schizophrenia. Postmortem human brain studies also provide evidence for reduction in Reelin mRNA (an important secretory protein responsible for normal lamination of the brain) in schizophrenic brains. We hypothesized that human influenza infection in day 9 pregnant mice would alter the expression of reelin in day 0 neonatal brains. Prenatally-infected murine brains from postnatal day 0 showed significant reductions in reelin-positive cell counts in layer 1 of neocortex and other cortical and hippocampal layers when compared to controls. Whereas layer 1 Cajal-Retzius cells produced significantly less Reelin in infected animals, the same cells showed normal production of calretinin and nNOS when compared to control brains. Moreover, prenatal viral infection caused decreases in neocortical and hippocampal thickness. These results implicate a potential role of prenatal viral infection in causation of neuronal migration abnormalities via reduction in Reelin production in neonatal brains.

元の言語English
ページ(範囲)145-154
ページ数10
ジャーナルMolecular Psychiatry
4
発行部数2
DOI
出版物ステータスPublished - 1999
外部発表Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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