Defects of Autologous Mixed Lymphocyte Reaction‐Activated Immunoregulatory T Cells in Patients with Systemic Lupus Erythematosus

J. KOIDE, T. TAKEUCHI, O. HOSONO, M. TAKANO, T. ABE

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The present study was undertaken to determine the nature of the immunoregulatory T‐cell defect after autologous mixed lymphocyte reaction (AMLR) activation in patients with systemic lupus erythematosus (SLE). Although AMLR was decreased in patients with SLE compared with normals, there was no difference in major proliferative cells (T4 cells and T4+JRA+ subset) in response to AMLR. Functional activity of AMLR‐stimulated T4 subsets in patients with SLE and normals was examined in helper and suppressor/inducer assay, using pokeweed mitogen (PWM)‐driven IgG synthesis. The T4+JRA (helper) subset from SLE patients showed no greater activity than normals. However the T4+JRA+ (suppressor/inducer) subset from SLE patients showed decreased suppression induction compared with normals. This defect in the suppressor/inducer function was demonstrated even in patients with inactive SLR or in remission.

本文言語English
ページ(範囲)363-369
ページ数7
ジャーナルScandinavian Journal of Immunology
26
4
DOI
出版ステータスPublished - 1987 10
外部発表はい

ASJC Scopus subject areas

  • 免疫学

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