Defining the role of Lgr5+ stem cells in colorectal cancer: From basic research to clinical applications

研究成果: Comment/debate査読

4 被引用数 (Scopus)

抄録

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5+ intestinal stem cells, providing insights into their roles in homeostasis and cancer.

本文言語English
論文番号66
ジャーナルGenome Medicine
9
1
DOI
出版ステータスPublished - 2017 7 18

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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