Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

Yasunori Okada, Hiroshi Konomi, Toshikazu Yada, Koji Kimata, Hideaki Nagase

研究成果: Article査読

83 被引用数 (Scopus)

抄録

The degradation of type IX collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (MMPs) purified from the culture medium of rheumatoid synovial cells. Neither MMP-1 (collagenase) nor MMP-2 (so-called 'gelatinase') could digest type IX collagen, but MMP-3 (stromelysin) readily degraded it into smaller fragments. This suggests that MMP-3 may be responsible for the pathological degradation and/or normal turnover of type IX collagen.

本文言語English
ページ(範囲)473-476
ページ数4
ジャーナルFEBS Letters
244
2
DOI
出版ステータスPublished - 1989 2月 27
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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