Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9

Kazushi Imai, Hideo Shikata, Yasunori Okada

研究成果: Article査読

56 被引用数 (Scopus)

抄録

The susceptibility of vitronectin (Vn) purified from human plasma to digestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesting 8-, 30- and 44-fold more preferentially than MMP-2, -3 and -9, respectively. These data suggest that MMP-2, -3, -7 and -9 may be responsible for the pathological degradation and/or normal turnover of Vn.

本文言語English
ページ(範囲)249-251
ページ数3
ジャーナルFEBS Letters
369
2-3
DOI
出版ステータスPublished - 1995 8 7

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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