TY - JOUR
T1 - Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9
AU - Imai, Kazushi
AU - Shikata, Hideo
AU - Okada, Yasunori
PY - 1995/8/7
Y1 - 1995/8/7
N2 - The susceptibility of vitronectin (Vn) purified from human plasma to digestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesting 8-, 30- and 44-fold more preferentially than MMP-2, -3 and -9, respectively. These data suggest that MMP-2, -3, -7 and -9 may be responsible for the pathological degradation and/or normal turnover of Vn.
AB - The susceptibility of vitronectin (Vn) purified from human plasma to digestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesting 8-, 30- and 44-fold more preferentially than MMP-2, -3 and -9, respectively. These data suggest that MMP-2, -3, -7 and -9 may be responsible for the pathological degradation and/or normal turnover of Vn.
KW - Degradation
KW - Kinetics
KW - Matrix metalloproteinase
KW - Vitronectin
UR - http://www.scopus.com/inward/record.url?scp=0029081738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029081738&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(95)00752-U
DO - 10.1016/0014-5793(95)00752-U
M3 - Article
C2 - 7544295
AN - SCOPUS:0029081738
SN - 0014-5793
VL - 369
SP - 249
EP - 251
JO - FEBS Letters
JF - FEBS Letters
IS - 2-3
ER -