Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes

Masayo Kagami, Yoichi Sekita, Gen Nishimura, Masahito Irie, Fumiko Kato, Michiyo Okada, Shunji Yamamori, Hiroshi Kishimoto, Masahiro Nakayama, Yukichi Tanaka, Kentarou Matsuoka, Tsutomu Takahashi, Mika Noguchi, Yoko Tanaka, Kouji Masumoto, Takeshi Utsunomiya, Hiroko Kouzan, Yumiko Komatsu, Hirofumi Ohashi, Kenji KurosawaKenjirou Kosaki, Anne C. Ferguson-Smith, Fumitoshi Ishino, Tsutomu Ogata

研究成果: Article査読

211 被引用数 (Scopus)

抄録

Human chromosome 14q32.2 carries a cluster of imprinted genes including paternally expressed genes (PEGs) such as DLK1 and RTL1 and maternally expressed genes (MEGs) such as MEG3 (also known as GTL2), RTL1as (RTL1 antisense) and MEG8 (refs. 1,2), together with the intergenic differentially methylated region (IG-DMR) and the MEG3-DMR. Consistent with this, paternal and maternal uniparental disomy for chromosome 14 (upd(14)pat and upd(14)mat) cause distinct phenotypes. We studied eight individuals (cases 1-8) with a upd(14)pat-like phenotype and three individuals (cases 9-11) with a upd(14)mat-like phenotype in the absence of upd(14) and identified various deletions and epimutations affecting the imprinted region. The results, together with recent mouse data, imply that the IG-DMR has an important cis-acting regulatory function on the maternally inherited chromosome and that excessive RTL1 expression and decreased DLK1 and RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively.

本文言語English
ページ(範囲)237-242
ページ数6
ジャーナルNature genetics
40
2
DOI
出版ステータスPublished - 2008 2

ASJC Scopus subject areas

  • Genetics

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