Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura; Shunichi Sato; Mitsuhiro Terakawa; Hitoshi Wakisaka; Maki Uenoyama; Tomosumi Ikeda; Hiroshi Ashida; Minoru Obara

doi:10.1143/jjap.42.l977

Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura, Shunichi Sato, Mitsuhiro Terakawa, Hitoshi Wakisaka, Maki Uenoyama, Tomosumi Ikeda, Hiroshi Ashida, Minoru Obara

電気情報工学科

研究成果: Letter › 査読

12 被引用数 (Scopus)

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We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm²), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm²). We also observed the nucleus membrane permeabilization induced by the LISW.

本文言語	English
ページ（範囲）	L977-L979
ジャーナル	Japanese Journal of Applied Physics, Part 2: Letters
巻	42
号	8 A
DOI	https://doi.org/10.1143/jjap.42.l977
出版ステータス	Published - 2003 8月 1

ASJC Scopus subject areas

工学（全般）
物理学および天文学（全般）

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10.1143/jjap.42.l977

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title = "Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse",

abstract = "We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.",

keywords = "Drug delivery, Laser-induced stress wave, Photodynamic therapy, Photofrin II, Photosensitizer, Q-switched Nd:YAG laser, Shock wave",

author = "Makoto Ogura and Shunichi Sato and Mitsuhiro Terakawa and Hitoshi Wakisaka and Maki Uenoyama and Tomosumi Ikeda and Hiroshi Ashida and Minoru Obara",

year = "2003",

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doi = "10.1143/jjap.42.l977",

language = "English",

volume = "42",

pages = "L977--L979",

journal = "Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes",

issn = "0021-4922",

publisher = "Japan Society of Applied Physics",

number = "8 A",

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TY - JOUR

T1 - Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

AU - Ogura, Makoto

AU - Sato, Shunichi

AU - Terakawa, Mitsuhiro

AU - Wakisaka, Hitoshi

AU - Uenoyama, Maki

AU - Ikeda, Tomosumi

AU - Ashida, Hiroshi

AU - Obara, Minoru

PY - 2003/8/1

Y1 - 2003/8/1

N2 - We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

AB - We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

KW - Drug delivery

KW - Laser-induced stress wave

KW - Photodynamic therapy

KW - Photofrin II

KW - Photosensitizer

KW - Q-switched Nd:YAG laser

KW - Shock wave

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U2 - 10.1143/jjap.42.l977

DO - 10.1143/jjap.42.l977

M3 - Letter

AN - SCOPUS:0141763569

VL - 42

SP - L977-L979

JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

SN - 0021-4922

IS - 8 A

ER -

Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

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