Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura; Shunichi Sato; Mitsuhiro Terakawa; Hitoshi Wakisaka; Maki Uenoyama; Tomosumi Ikeda; Hiroshi Ashida; Minoru Obara

doi:10.1143/jjap.42.l977

Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura, Shunichi Sato, Mitsuhiro Terakawa, Hitoshi Wakisaka, Maki Uenoyama, Tomosumi Ikeda, Hiroshi Ashida, Minoru Obara

電気情報工学科

研究成果: Letter › 査読

12 被引用数 (Scopus)

抄録

We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm²), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm²). We also observed the nucleus membrane permeabilization induced by the LISW.

本文言語	English
ページ（範囲）	L977-L979
ジャーナル	Japanese Journal of Applied Physics, Part 2: Letters
巻	42
号	8 A
DOI	https://doi.org/10.1143/jjap.42.l977
出版ステータス	Published - 2003 8 1

ASJC Scopus subject areas

工学（全般）
物理学および天文学（その他）
物理学および天文学（全般）

文献へのアクセス

10.1143/jjap.42.l977

他のファイルとリンク

引用スタイル

Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse. / Ogura, Makoto; Sato, Shunichi; Terakawa, Mitsuhiro; Wakisaka, Hitoshi; Uenoyama, Maki; Ikeda, Tomosumi; Ashida, Hiroshi; Obara, Minoru.

In: Japanese Journal of Applied Physics, Part 2: Letters, Vol. 42, No. 8 A, 01.08.2003, p. L977-L979.

研究成果: Letter › 査読

@article{8b16bbcb98364004b4bf1a8161665bd3,

title = "Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse",

abstract = "We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.",

keywords = "Drug delivery, Laser-induced stress wave, Photodynamic therapy, Photofrin II, Photosensitizer, Q-switched Nd:YAG laser, Shock wave",

author = "Makoto Ogura and Shunichi Sato and Mitsuhiro Terakawa and Hitoshi Wakisaka and Maki Uenoyama and Tomosumi Ikeda and Hiroshi Ashida and Minoru Obara",

year = "2003",

month = aug,

day = "1",

doi = "10.1143/jjap.42.l977",

language = "English",

volume = "42",

pages = "L977--L979",

journal = "Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes",

issn = "0021-4922",

publisher = "Japan Society of Applied Physics",

number = "8 A",

}

TY - JOUR

T1 - Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

AU - Ogura, Makoto

AU - Sato, Shunichi

AU - Terakawa, Mitsuhiro

AU - Wakisaka, Hitoshi

AU - Uenoyama, Maki

AU - Ikeda, Tomosumi

AU - Ashida, Hiroshi

AU - Obara, Minoru

PY - 2003/8/1

Y1 - 2003/8/1

N2 - We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

AB - We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

KW - Drug delivery

KW - Laser-induced stress wave

KW - Photodynamic therapy

KW - Photofrin II

KW - Photosensitizer

KW - Q-switched Nd:YAG laser

KW - Shock wave

UR - http://www.scopus.com/inward/record.url?scp=0141763569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141763569&partnerID=8YFLogxK

U2 - 10.1143/jjap.42.l977

DO - 10.1143/jjap.42.l977

M3 - Letter

AN - SCOPUS:0141763569

VL - 42

SP - L977-L979

JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

SN - 0021-4922

IS - 8 A

ER -

Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル