We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.
|ジャーナル||Japanese Journal of Applied Physics, Part 2: Letters|
|出版物ステータス||Published - 2003 8 1|
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)
- Physics and Astronomy(all)