Delivery of photosensitizer to cells by the stress wave induced by a single nanosecond laser pulse

Makoto Ogura, Shunichi Sato, Mitsuhiro Terakawa, Hitoshi Wakisaka, Maki Uenoyama, Tomosumi Ikeda, Hiroshi Ashida, Minoru Obara

研究成果: Letter

12 引用 (Scopus)

抜粋

We demonstrated that porfimer sodium (Photofrin II) was delivered into cells by applying a single nanosecond pulsed laser-induced stress wave (LISW). Analysis with a confocal laser scanning microscope showed that Photofrin molecules were homogeneously distributed in the cytoplasm at a low fluence (0.25 J/cm2), while the molecules were accumulated in a specific site at a high fluence (0.50 J/cm2). We also observed the nucleus membrane permeabilization induced by the LISW.

元の言語English
ページ(範囲)L977-L979
ジャーナルJapanese Journal of Applied Physics, Part 2: Letters
42
発行部数8 A
DOI
出版物ステータスPublished - 2003 8 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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