Dendritic cell based personalized immunotherapy based on cancer antigen research

Yutaka Kawakami, Tomonobu Fujita, Chie Kudo, Toshiharu Sakurai, Masaru Udagawa, Tomonori Yaguchi, Go Hasegawa, Emiko Hayashi, Yoko Ueda, Tomoko Iwata, Qinfu Wang, Starlyn Okada, Nobuo Tsukamoto, Yuriko Matsuzaki, Hidetoshi Sumimoto

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

Human tumor antigens were identified using various immunological and genetic methods, and immune responses to the identified antigens were evaluated in cancer patients. Autologous tumor specific unique antigens derived from genetic alterations in cancer cells were isolated from patients with favorable prognosis after immunotherapy, indicating that they are attractive targets for immunotherapy. Immunogenicity of shared antigens was found to differ among patients due to antigen expression in cancer cells and patients' immunoreactivity. These observations suggest that personalization may be applied for cancer immunotherapy. We therefore developed intratumoral DC administration protocols that are able to induce immune responses to both unique and shared tumor antigens expressed in each individual cancer. By combining cryoablative tumor pretreatment and TLR stimulated DC, the anti-tumor effect of the intratumoral DC administration was significantly augmented in a murine tumor model. This improved protocol enhanced systemic induction of anti-tumor CD8 + CTL, and was able to regress relatively large remote untreated tumors. In clinical trials, systemic immune induction was observed by intraturmoral DC administration following cryoablative tumor treatment, although anti-tumor effects are relatively weak, indicating that additional interventions are required for more effective immunotherapy.

本文言語English
ページ(範囲)1952-1958
ページ数7
ジャーナルFrontiers in Bioscience
13
5
DOI
出版ステータスPublished - 2008

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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