Depth-targeted transvascular drug delivery by using annular-shaped photomechanical waves

Takuya Akiyama, Shunichi Sato, Hiroshi Ashida, Mitsuhiro Terakawa

    研究成果: Conference contribution

    2 被引用数 (Scopus)

    抄録

    Laser-based drug delivery is attractive for the targeting capability due to high spatial controllability of laser energy. Recently, we found that photomechanical waves (PMWs) can transiently increase the permeability of blood vessels in skin, muscle and brain of rats. In this study, we examined the use of annular-shaped PMWs to increase pressure at target depths due to superposition effect of pressure waves. This can increase the permeability of blood vessels located in the specific depth regions, enabling depth-targeted transvascular drug delivery. Annular PMWs were produced by irradiating a laser-absorbing material with annular-shaped pulsed laser beams that were produced by using an axicon lens. We first examined propagation and pressure characteristics of annular PMWs in tissue phantoms and confirmed an increased pressure at a target depth, which can be controlled by changing laser parameters. We injected Evans blue (EB) into a rat tail vein, and annular PMWs (inner diameter, 3 mm; outer diameter, 5 mm) were applied from the myofascial surface of the anterior tibialis muscle. After perfusion fixation, we observed fluorescence originating from EB in the tissue. We observed intense fluorescence at a target depth region of around 5 mm. These results demonstrate the capability of annular PMWs for depth-targeted transvascular drug delivery.

    本文言語English
    ホスト出版物のタイトルImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
    DOI
    出版ステータスPublished - 2011 4 20
    イベントImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX - San Francisco, CA, United States
    継続期間: 2011 1 222011 1 25

    出版物シリーズ

    名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    7902
    ISSN(印刷版)1605-7422

    Other

    OtherImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
    国/地域United States
    CitySan Francisco, CA
    Period11/1/2211/1/25

    ASJC Scopus subject areas

    • 電子材料、光学材料、および磁性材料
    • 生体材料
    • 原子分子物理学および光学
    • 放射線学、核医学およびイメージング

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