TY - CHAP
T1 - DESI-based imaging mass spectrometry in forensic science and clinical diagnosis
AU - Sugiura, Yuki
AU - Sugiyama, Eiji
AU - Suematsu, Makoto
N1 - Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - In the decades following the successful introduction of two soft ionization methods, viz., matrix-assisted laser desorption ionization (MALDI) and electrospray ionization ESI, several promising and practical techniques have been developed to perform ionization under ambient conditions. Desorption electrospray ionization (DESI) is one of the most popular ambient ionization methods and has been implemented in numerous fields. Imaging mass spectrometry (IMS) coupled with DESI is among the most successful of these applications, particularly in the fields of forensic science and molecular biology. Unlike MALDI based IMS which involves a matrix application process, sample preparation for DESI-IMS is a simple and minimal procedure that can be potentially performed by nonexperts, including hospital laboratory technicians. Moreover, DESI enables surface analysis of various materials under ambient conditions. Skin, glass, rubber, and even cotton can be analyzed using this ionization technique. Thus, DESI is versatile in situations typically encountered in forensic analysis. Rapid and facile DESI-based chemical detection and IMS are practical methods for forensic testing and clinical diagnosis.
AB - In the decades following the successful introduction of two soft ionization methods, viz., matrix-assisted laser desorption ionization (MALDI) and electrospray ionization ESI, several promising and practical techniques have been developed to perform ionization under ambient conditions. Desorption electrospray ionization (DESI) is one of the most popular ambient ionization methods and has been implemented in numerous fields. Imaging mass spectrometry (IMS) coupled with DESI is among the most successful of these applications, particularly in the fields of forensic science and molecular biology. Unlike MALDI based IMS which involves a matrix application process, sample preparation for DESI-IMS is a simple and minimal procedure that can be potentially performed by nonexperts, including hospital laboratory technicians. Moreover, DESI enables surface analysis of various materials under ambient conditions. Skin, glass, rubber, and even cotton can be analyzed using this ionization technique. Thus, DESI is versatile in situations typically encountered in forensic analysis. Rapid and facile DESI-based chemical detection and IMS are practical methods for forensic testing and clinical diagnosis.
KW - Clinical diagnosis
KW - Desorption electrospray ionization (DESI)
KW - Forensic science
KW - Imaging mass spectrometry (IMS)
KW - Reactive DESI
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U2 - 10.1016/B978-0-12-817220-9.00004-7
DO - 10.1016/B978-0-12-817220-9.00004-7
M3 - Chapter
AN - SCOPUS:85093485149
SP - 107
EP - 118
BT - Ambient Ionization Mass Spectrometry in Life Sciences
PB - Elsevier
ER -