Design and synthesis of 1-thia-3,8-diyn-5-ene systems with DNA-cleaving properties related to the neocarzinostatin chromophore

Kazunobu Toshima, Kazumi Ohta, Aya Ohashi, Atsuo Ohtsuka, Masaya Nakata, Kuniaki Tatsuta

研究成果: Article査読

16 被引用数 (Scopus)

抄録

1-Thia-3,8-diyn-5-ene compounds 5-10, which are derivatives of the parent compound 1 are synthesized in a short step with high stability; these compounds show DNA-cleaving activity under basic conditions in the absence of any additives.

本文言語English
ページ(範囲)1306-1308
ページ数3
ジャーナルJournal of the Chemical Society, Chemical Communications
18
DOI
出版ステータスPublished - 1992 12 1

ASJC Scopus subject areas

  • Molecular Medicine

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