Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring-opening process of rhodamine derivatives

Hiromi Sasaki, Kenjiro Hanaoka, Yasuteru Urano, Takuya Terai, Tetsuo Nagano

研究成果: Article査読

58 被引用数 (Scopus)

抄録

The spirolactam ring-opening process of rhodamine derivative is one of the most useful mechanisms for controlling fluorescence properties. However, the open/closed equilibrium reaction of rhodamine spirolactam has not been well characterized. Therefore, we examined the relationship between the spirolactam ring-opening process of rhodamine derivatives and the structure of the xanthene moiety. Based on the results of this investigation, we selected a candidate xanthene moiety for a Zn2+ sensor, and successfully developed a new fluorescence probe for Zn2+.

本文言語English
ページ(範囲)1072-1078
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
19
3
DOI
出版ステータスPublished - 2011 2 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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