Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity

Mitsuhiro Arisawa; Yayoi Kasaya; Tohru Obata; Takuma Sasaki; Tomonori Nakamura; Takuya Araki; Koujirou Yamamoto; Akito Sasaki; Akihito Yamano; Mika Ito; Hiroshi Abe; Yoshihiro Ito; Satoshi Shuto

doi:10.1021/jm301084z

Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity

Mitsuhiro Arisawa, Yayoi Kasaya, Tohru Obata, Takuma Sasaki, Tomonori Nakamura, Takuya Araki, Koujirou Yamamoto, Akito Sasaki, Akihito Yamano, Mika Ito, Hiroshi Abe, Yoshihiro Ito, Satoshi Shuto

研究成果: Article › 査読

26 被引用数 (Scopus)

抄録

We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.

本文言語	English
ページ（範囲）	8152-8163
ページ数	12
ジャーナル	Journal of Medicinal Chemistry
巻	55
号	18
DOI	https://doi.org/10.1021/jm301084z
出版ステータス	Published - 2012 9月 27
外部発表	はい

ASJC Scopus subject areas

分子医療
創薬

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10.1021/jm301084z

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「Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Arisawa, M., Kasaya, Y., Obata, T., Sasaki, T., Nakamura, T., Araki, T., Yamamoto, K., Sasaki, A., Yamano, A., Ito, M., Abe, H., Ito, Y., & Shuto, S. (2012). Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity. Journal of Medicinal Chemistry, 55(18), 8152-8163. https://doi.org/10.1021/jm301084z

Arisawa, M, Kasaya, Y, Obata, T, Sasaki, T, Nakamura, T, Araki, T, Yamamoto, K, Sasaki, A, Yamano, A, Ito, M, Abe, H, Ito, Y & Shuto, S 2012, 'Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity', Journal of Medicinal Chemistry, vol. 55, no. 18, pp. 8152-8163. https://doi.org/10.1021/jm301084z

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AU - Sasaki, Takuma

AU - Nakamura, Tomonori

AU - Araki, Takuya

AU - Yamamoto, Koujirou

AU - Sasaki, Akito

AU - Yamano, Akihito

AU - Ito, Mika

AU - Abe, Hiroshi

AU - Ito, Yoshihiro

AU - Shuto, Satoshi

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