Design of Hollow Protein Nanoparticles with Modifiable Interior and Exterior Surfaces

Norifumi Kawakami, Hiroki Kondo, Yuki Matsuzawa, Kaoru Hayasaka, Erika Nasu, Kenji Sasahara, Ryoichi Arai, Kenji Miyamoto

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Protein-based nanoparticles hold promise for a broad range of applications. Here, we report the production of a uniform anionic hollow protein nanoparticle, designated TIP60, which spontaneously assembles from a designed fusion protein subunit based on the geometric features of polyhedra. We show that TIP60 tolerates mutation and both its interior and exterior surfaces can be chemically modified. Moreover, TIP60 forms larger structures upon the addition of a cationic protein. Therefore, TIP60 can be used as a modifiable nano-building block for further molecular assembly.

本文言語English
ページ(範囲)12400-12404
ページ数5
ジャーナルAngewandte Chemie - International Edition
57
38
DOI
出版ステータスPublished - 2018 9 17

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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