TY - JOUR
T1 - Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices
AU - Kono, R.
AU - Ota, T.
AU - Ito, T.
AU - Miyaoka, Y.
AU - Ishibashi, H.
AU - Kanno, Y.
AU - Miki, N.
N1 - Funding Information:
*Research supported by AMED Foundation.
Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.
AB - In order to improve the quality of life of dialysis patients, our group have been developing an implantable hemofiltration device (IHFD) composed of multiple layers of dialysis membranes and microfluidic channels. To improve the hemodialysis performance of IHFD, preventing the negative filtration, which is caused by the oncotic pressure of blood, is mandatory. In this study, we fabricated IHFDs with five different microchannel designs and experimentally investigated the performance of each device in in vitro experiment. In addition, the successful IHFD was further evaluated by ex vivo experiments with a beagle dog. The experiments verified the effectiveness of the microchannel design, which will be used for the IHFD for in vivo experiments with pigs in the future.
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U2 - 10.1109/EMBC46164.2021.9630070
DO - 10.1109/EMBC46164.2021.9630070
M3 - Conference article
C2 - 34892342
AN - SCOPUS:85122509729
SN - 1557-170X
VL - 2021-January
SP - 5051
EP - 5054
JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
T2 - 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2021
Y2 - 1 November 2021 through 5 November 2021
ER -